PTG1 forms complexes with nucleic acids that can be encapsulated in liposomes to form nanoparticles called Lipopolyplexes or LPR which increase transfection efficiency
LPR allow in vivo transfections of mRNA and microRNA.
Simion et al., Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system. J. Controlled Release 2020, 327:429-443.
Wang et al., In Vivo bone tissue induction by freeze-dried collagen-nanohydroxyapatite matrix loaded with BMP2/NS1 mRNAs lipopolyplexes. J.Controlled Release 2021; 334; 188–200.